cKO Mouse Model
Our core platform is based on a proprietary male mouse stem cell technology derived from the groundbreaking Nature publication "Establishment of Mouse Expanded Potential Stem Cells" by our founder, Dr. Lan Guocheng. This innovative approach ensures 100% gene editing efficiency, a benchmark consistently validated across multiple projects.
Through systematic optimization of our embryonic stem cell injection protocol, we can achieve complete embryonic development solely from the injected stem cells, with no recipient embryo contribution to fetal tissues.
Core Technical Services:
• Developmental Potential Assessment
- Evaluation of developmental competence for both mouse and non-mouse stem cells
- Comprehensive analysis of stem cell totipotency and extra-embryonic differentiation capability
• Cross-Species Development Research
- Investigation of developmental interactions between heterologous stem cells and mouse embryonic environments
• Embryo Sampling and Culture
- Provision of precisely-staged mouse embryos (E5.5-E7.5)
- Support for ex vivo embryo culture systems maintaining viability for 48+ hours
• Custom Model Generation
- Delivery of genetically engineered mouse models within 4 months
- Specialization in complex models including targeted large-fragment DNA integration
